منابع مشابه
Microtubule-severing enzymes at the cutting edge.
ATP-dependent severing of microtubules was first reported in Xenopus laevis egg extracts in 1991. Two years later this observation led to the purification of the first known microtubule-severing enzyme, katanin. Katanin homologs have now been identified throughout the animal kingdom and in plants. Moreover, members of two closely related enzyme subfamilies, spastin and fidgetin, have been found...
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Objective: Cardiac hypertrophy is a complex phenotype induced by a number of stimuli and may lead to cardiomyopathy and heart failure. Present knowledge suggests that cell cycle regulatory proteins take part in the development of hypertrophy. We have investigated the activation and regulation of the E2F transcription factor during the hypertrophic response. Methods: The expression and activity ...
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“The bigger they are, the harder they fall” is a bit of wisdom that’s been around for a long time. But when it comes to pesticide application, the line should read, “The bigger they are, the closer they fall.” Large droplets are not as likely to drift off-target as smaller droplets. This basic principle lies behind many innovations to reduce drift when spraying herbicides. Nozzle manufacturers ...
متن کاملThe Cutting Edge
A 17-year-old white woman presented with a 2-year history of increasingly frequent episodes of erythromelalgia involving her hands, feet, and lower legs (Figure). She described the discomfort as “throbbing, burning, stinging.” Her symptoms occurred daily. The episodes involved her feet about 10 to 15 times during the day and involved her hands slightly less frequently. Whenever her feet got war...
متن کاملThe Cutting Edge
Ming H. Jih, MD, PhD; Paul M. Friedman, MD; Arash Kimyai-Asadi, MD; Edward S. Friedman, MD; Sharon R. Hymes, MD; Leonard H. Goldberg, MD; DermSurgery Associates (Drs Jih, P. M. Friedman, Kimyai-Asadi, and Goldberg), The University of Texas School of Medicine (Dr P. M. Friedman), Baylor College of Medicine (Dr E. S. Friedman), and The University of Texas M. D. Anderson Cancer Center (Drs Hymes a...
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ژورنال
عنوان ژورنال: Eye
سال: 2020
ISSN: 0950-222X,1476-5454
DOI: 10.1038/s41433-020-01268-1